|
|Section3= |Section5= }} Methanesulfonyl fluoride (MSF) has long been known to be a potent inhibitor of acetylcholinesterase AChE, the enzyme that regulates acetylcholine, an important neurotransmitter in both the central and peripheral nervous systems. ==Technical and physical properties== MSF is a clear, colorless to yellowish hygroscopic liquid (attracts and holds water by absorption or adsorption). It is corrosive and highly toxic. It is an oxydiaphoric inhibitor (acid-transferring inhibitor)〔 of the enzyme acetylcholinesterase.〔 MSF, which is a liquid at room temperature, has a vapor pressure of 19.2 mmHg, slightly more volatile than water which has a vapor pressure of 18.8 mmHg at 21 °C. This vapor has an LCt50 (lethal concentration, 50% death rate in a given time) in rats of between 4 and 5 parts per million (ppm) during one hour of exposure or between 1 and 1.2 ppm during 7 hours of exposure. MSF produced no subtle biological effects from direct action of MSF independent of its ability to inhibit cholinesterase. Repeated exposures to 1/10 of the LCt50 did not produce overt systemic toxicity or significant pathology. MSF can also cause severe skin burns and serious eye damage, if contact is made. It is a lachrymator and its vapor causes tears in eyes.〔(MSDS ), Fisher Scientific〕〔 Methanesulfonyl fluoride has a pungent odor. It undergoes decomposition on heating to liberate additional toxic fumes of fluorides and sulfur oxides (SOx). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Methanesulfonyl fluoride」の詳細全文を読む スポンサード リンク
|